Archaea Bioprocess Technology

TwentyGreen® develops advanced bioprocess technologies for the cultivation of beneficial gut archaea. Building on discoveries in microbiome science, our platform enables the scalable fermentation and production of Methanobrevibacter smithii, the dominant archaeon in the human gut microbiome.

Industrial cultivation of anaerobic gut microorganisms has historically been extremely challenging due to strict oxygen sensitivity and complex metabolic requirements. TwentyGreen’s proprietary fermentation technologies overcome these barriers and enable controlled production of archaeal biomass for research, diagnostics and therapeutic applications.

This capability opens new opportunities across the microbiome field including:

1. Development of next-generation archaeal microbiome therapeutics
2. Biobanking and discovery of novel archaeal strains
3. Production of archaeal biomass for scientific research
4. Industrial fermentation of anaerobic gut microorganisms

By enabling scalable cultivation of Methanobrevibacter smithii, TwentyGreen establishes a new technological foundation for translating archaeal microbiome discoveries into practical health applications.

The ability to cultivate beneficial human gut archaea at scale represents a major technological milestone for microbiome science. By combining microbial ecology, fermentation engineering and microbiome research, TwentyGreen contributes to the development of next-generation microbiome technologies for diagnostics, therapeutics and precision health.